Estudo potencializa imunoterapia usada contra câncer no sangue

[{"selector":"#anim-8c5ec3c1-4ac9-4c63-846c-b0cd4c50efa2","keyframes":{"opacity":[0,1]},"delay":0,"duration":1000,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-99198013-b28e-45c5-88e5-bc8827a2d1da","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-29f28bd0-102a-4c70-9e54-f5ec81742acc","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-8f8eb537-8327-496b-8ea3-37d51abd82ae","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] Unsplash

[{"selector":"#anim-6280b983-c6bc-4208-ba11-783930037f67","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-16e009cd-a611-4f8a-bdc2-c26d21a7d47f","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-c762d09a-9f05-442c-8a46-6d0ec787d8af","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-b68136ab-da78-4b41-b55d-4fb4b3f9f7de","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-1a63a969-f5bc-4e90-a0a5-da7df7bd0682 [data-leaf-element=\"true\"]","keyframes":{"transform":["translate3d(31.249999886225726%, 0, 0)","translate3d(0%, 0, 0)"]},"delay":0,"duration":2000,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] Pesquisadores brasileiros desenvolveram uma versão mais potente das células CAR-T para tratar pacientes com linfoma não Hodgkin e leucemia linfoblástica aguda que não respondem à imunoterapia convencional Unsplash

[{"selector":"#anim-193bcae9-4e52-49e9-98dc-40c146ad4af4","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-7dbba09b-2847-4285-b03d-8824b897cfe2","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-2de987fd-c438-4296-ad03-2b73d3895f9c","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-c93157a7-f498-42f9-a2b9-359d0b1b9f21","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-3a8b3f0d-8b75-4235-981a-fa18d0af3ebe [data-leaf-element=\"true\"]","keyframes":{"transform":["translate3d(-24.99999988622573%, 0, 0)","translate3d(0%, 0, 0)"]},"delay":0,"duration":2000,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] A inovação consistiu em adicionar um inibidor do complexo PRC2 às células CAR-T, eliminando freios epigenéticos que limitavam sua ação contra os tumores Unsplash

[{"selector":"#anim-a9b09236-2d77-44a8-b29e-9a92918b21cd","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-717d0715-e692-4458-8257-5cb67b19f5e5","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-a3e89f21-e393-40d9-94b4-943189012fac","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-8bf1794f-3d34-4df8-b4d2-d4d94e4e1acd","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] Os testes in vitro e em camundongos mostraram que essas células modificadas foram mais eficientes e rápidas na eliminação dos tumores em comparação com as CAR-T tradicionais Unsplash

[{"selector":"#anim-f4a37d8e-00b8-4684-a0aa-8b1e71afd719","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-548c0689-92a7-42f4-b133-4382a5ec3815","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-69dc6b60-36d6-4363-958f-3f216cb38d59","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-58ff5011-e8fb-4505-8cf1-a1b560bdd7f3","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-43ff2cca-2091-46b8-be22-2ef14cab4768 [data-leaf-element=\"true\"]","keyframes":{"transform":["translate3d(31.249999886225726%, 0, 0)","translate3d(0%, 0, 0)"]},"delay":0,"duration":2000,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] Nos experimentos com animais, as células modificadas também demonstraram uma resposta mais persistente, sem sinais imediatos de toxicidade sistêmica Unsplash

[{"selector":"#anim-e0990356-8b2d-4b29-a1fd-ab9181715fc1","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-23997d90-ca99-4de6-8643-41e5cea80617","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-0cc3b785-fe20-4de1-b8a9-6c0bead46f77","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-babc7dc5-6bff-48f0-8f0e-2dcb69aedb22","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-837d55e3-fc8d-4ec8-95c4-669ad5ab183b [data-leaf-element=\"true\"]","keyframes":{"transform":["translate3d(37.79912022729434%, 0, 0)","translate3d(0%, 0, 0)"]},"delay":0,"duration":2000,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] Agora, os pesquisadores irão investigar os possíveis efeitos colaterais da nova abordagem, especialmente o risco de inflamação exacerbada Unsplash

[{"selector":"#anim-d9b15591-0f36-414d-99f5-f4001334aacb","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-1432decb-321d-47e7-bfc2-6b25cc8850f2","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-714a127e-4a34-4a9e-b910-73c9248866dc","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-0c64f2a1-2f24-43ae-a198-3c4d1134e6c2","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-34297711-6c64-4e0a-a2f4-43d06d5c1ce7 [data-leaf-element=\"true\"]","keyframes":{"transform":["translate3d(-7.726926721176253%, 0, 0)","translate3d(0%, 0, 0)"]},"delay":0,"duration":2000,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] Se comprovada a segurança, a técnica poderá ser incorporada à fabricação das células CAR-T, aumentando sua eficácia contra certos tipos de câncer sem elevar os riscos ao paciente Unsplash

CNNBRASIL.COM.BR

[{"selector":"#anim-f30b8097-fd69-4138-b7d4-68c1aff0ef33","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-c629d8b1-a18f-46db-a800-445d03594316","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-cbdf61bc-e9fe-4dda-ac5d-25a9676a1410","keyframes":{"opacity":[0,1]},"delay":0,"duration":1000,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-e578e9d1-4e97-4cca-8084-089839e1270d","keyframes":{"transform":["translate3d(0px, 2132.63615%, 0)","translate3d(0px, 0px, 0)"]},"delay":0,"duration":1000,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-c519f0b6-e392-429e-84bd-6f76be3c5868","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-a9d5f465-42a2-4a4c-983b-8ae99c6eaeb8","keyframes":{"transform":["translate3d(-117.84387%, 0px, 0)","translate3d(0px, 0px, 0)"]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-7e59b888-6914-4f67-8cc3-19832788ad3f","keyframes":{"opacity":[0,1]},"delay":0,"duration":1000,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-73142609-11e4-483a-a480-8b2d0ae866f6","keyframes":{"transform":["translate3d(0px, 1235.47011%, 0)","translate3d(0px, 0px, 0)"]},"delay":0,"duration":1000,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] Unsplash leia mais em